This study focused on the biosensing detection of liver function biomarkers: alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The proposed biosensor technology was clinically useful tool for potential point-of-care screening of liver status. Electrochemical sensing techniques, and screen printing fabrication promised a large-scaled production of portable sensor prototype in a cost-effective way.Furthermore, the sensor operation was easy-used for a rapid detection. Also, incorporating nano-catalyst into sensor design allowed a selective performance, especially on the measurement of human physiological fluids. To develop a full prototype of biosensor platform, a stable and well-performed bio-recognition component was essential. In this study, introducing ionic liquid as a modifier into biosensing application endowed enzyme-based ALT and glucose sensors with high stability and high sensitivity, respectively.

Chang-Jung (Alan) Hsueh, PhD, Chemical Engineering at Case Western Reserve University. Extensive research experience in electrochemical engineering and biomedical sensor. Postdoctoral researcher at Electronics Design Center, Case Western Reserve University, United States.