This edited book describes what fragile bone is, how the condition is assessed, and how it can be treated. It is intended for multi-professional students and trainees in health and social care fields who care for and treat the elderly.Chapters within the book provide the latest advances in cell and molecular biology, morphology, radiology, and the biomechanics of bone in health and disease. The basic concept of "Remodeling" and "Modeling" is described for better understanding of the mechanisms of osteoporosis. Methods of identifying and assessing osteoporosis are described, as are risk factors for bone fracture and non-unions. Furthermore, the effects at both material and structural levels of bone of various drugs used to treat osteoporosis and their cost effectiveness are described. Operative treatments for fracture that maintain or improve the quality of life of patients are included.Treatment of Osteoporotic Fracture and Systemic Skeletal Disorders attempts to provide a holistic and translational view of the pathogenesis and treatment of osteoporosis and some other musculoskeletal diseases, with an overview of treatment modalities in various clinical settings.

Hideaki E. Takahashi, MD, PhDProfessor Emeritus, Niigata UniversityFormer Chair, Orthopaedic Department Niigata UniversityPresident Emeritus, Niigata University of Health and WelfareConsultant, Niigata Bone Science Institute David B. Burr, PhD, FAAADistinguished Professor, Indiana UniversityAssociate Vice Chancellor for Research, IUPUI Dept. of Anatomy and Cell BiologyDept. of Biomedical EngineeringIndiana University School of Medicine Noriaki Yamamoto, MD, PhD Director, Niigata Rehabilitation HospitalHead, Orthopaedic Department, Niigata Rehabilitation HospitalDirector, Niigata Bone Science InstituteSecretary General, NPO Fragility Fracture Network-Japan