Proceedings of the14th European Microscopy Congress, held in Aachen, Germany, 1-5 September 2008. Jointly organised by the European Microscopy Society (EMS), the German Society for Electron Microscopy (DGE) and the local microscopists from RWTH Aachen University and the Research Centre Jülich, the congress brings together scientists from Europe and from all over the world. The scientific programme covers all recent developments in the three major areas of instrumentation and methods, materials science and life science.

InhaltsangabeLife Science.- Cryoelectron microscopy: from molecules to systems.- Progress in High-resolution Scanning Probe Microscopy.- Analysis of macromolecules and their supramolecular assemblies.- Modular organization of RNase P.- Molecular anatomy of the human pathogen Leptospira interrogans.- Unveiling conformational changes of biological molecules using multiscale modeling and multiresolution experiments.- Nicolas Boisset: In memoriam.- Cryo TEM-based 3D reconstruction of the recombinant expressed human zinc peptidase Meprin ?.- Origin melting by SV40 Large T antigen-new insights from 3D-EM-MLF3D classification method.- Sequence analysis and modelling of the two large subunits of Phosphorylase Kinase.- Cellular Uptake of Polymer Nanoparticles Imaged by Electron Microscopy.- 9 Å cryo-EM structure and molecular model of a gastropod hemocyanin didecamer (KLH1) reveals the architecture of the asymmetric collar.- Microstructure of model systems for sauces based in polysacharides observed by Cryo-SEM.- Three-dimensional architecture of outer- and inner-dynein arms in flagella revealed by cryo-electron tomography and single particle analysis.- Structural and functional studies of rabbit skeletal muscle Phosphorylase Kinase.- Single-particle analysis of the Cdc6/Orc1, archaeal DNA replication initiator protein.- A high-throughput acquisition toolbox in Matlab for cryo-electron microscopy studies.- Architecture of bacterial glutamate synthase complexe using hybrid approaches.- 3D Structure of DNA Repair Macromolecular Complexes Participating in Non-Homologous End-Joining (NHEJ).- Quaternary structure of recombinant human meprin ?, a zinc peptidase of the astacin family.- Allosterism of Nautilus pompilius hemocyanin as deduced from 8 Å cryo-EM structures obtained under oxy and deoxy conditions.- High resolution structure of a 6 MDa protease by xray-crystallography and cryo-EM.- Cryo-TEM of liquid crystalline particles: Application of materials science techniques to study liquid crystalline particle structures.- Structural basis for the concerted integration of HIV-1 DNA in the human genome, role of the human cofactor LEDGF/p75.- Titan Krios: Automated 3D imaging at ambient and cryogenic conditions.- Self assembly and phase behaviour of new sugar based gemini amphiphiles.- Peptide-nanotube formation by lysine based lipoamino acids.- Advances in biological microanalysis using event streamed spectrum imaging and programmed beam acquisition.- 3D-correlation-averaging for membrane-protein-crystals.- 8 Å cryo-EM structure of the giant hemoglobin from the planorbid snail Biomphalaria glabrata.- Structure of Pex5p and Pex5-20 complexes in the yeast Hansenula polymorpha. Pex20p causes a conformational change upon binding to Pex5p tetramers involved in peroxisomal protein transport.- Structure of OprM-MexA interacting complex revealed by cryo electron tomography.- Cell Structure and Dynamics.- Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses.- Combined structural and chemical analysis of unique anammox bacteria that contain a prokaryotic organelle.- Structural and functional considerations on the 3-D organization of the fenestrated cytoplasm of hepatic endothelial cells.- Molecular architecture of the presynaptic compartment studied by cryo-electron tomography.- Synapses in high pressure frozen Caenorhabditis elegans.- High resolution EM-tomography of a whole vitrified cell.- Evaluation of beam damage in catalase crystals observed in vitrified sections.- Urothelial fusiform vesicles are formed in post-Golgi compartment.- Localisation of GFP and GFP tagged PKD2 in cultivated pancreatic cancer cells using high-pressure freezing.- Cytomegalovirus membrane envelopment revisited - a STEM-tomography study based on high-pressure freezing and freeze substitution.- Electron tomography & template matching of biological membranes.- Correlated Microscopy: From Dynamics to Structure.- 3DEM-analyses of Golgi apparatus subunits during